Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis\ndepends both on genetic factors and environment. PsA patients\nmay present a wide range of clinical manifestations including skin and nail\nabnormalities. Indeed, articular involvement is variable too. Disease development\nrelies on a heterogeneous net made of multiple cytokines pathways\nwhich are regulated by several factors including human leucocyte antigen\n(HLA) expression, miRNAs, microbiome. Among genetic polymorphisms\nwhich can lead to abnormal cytokine expression, tumor necrosis factor (TNF)\npolymorphisms have been studied. Thus, leading to the development of new\ntherapeutic agents. Finally, further studies on genetic factors and epigenetics\nwill give new insights into this complex disorder. The aim of this mini-review\nis to provide the reader with a summary of the fundamental and most innovative\naspects of genetic and epigenetic factors involved in the PsA, thus including\nhuman leucocyte antigen (HLA) expression, tumor necrosis factor\n(TNF) polymorphisms, micro RNAs and microbiome.
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